Topical tacrolimus ointment may induce skin tags in treated patients.

Sir, Tacrolimus onitment for the treatment of atopic dermatitis has recently received marketing approval under the trade name Protopic. According to the approved summary of product characteristics the known local side effects include: burning sensation, itching and erythema, folliculitis, acneiform eruption and eczema herpeticum. In addition, flushing or skin irritation may occur after intake of alcohol. We have seen that patients develop multiple skin tags on the neck and femoral folds during treatment with tacrolimus ointment 0.1%. This has not previously been reported in the literature.